产品货号：
Z21088
中文名称：
Mouse Ctr9抗体
英文名称：
Anti-Mouse Ctr9 Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Mouse Ctr9 Antibody (C-term) |
| 指标别名 | RNA polymerase-associated protein CTR9 homolog,SH2 domain-binding protein 1,Tetratricopeptide repeat-containing,SH2-binding phosphoprotein of 150kDa,TPR-containing,SH2-binding phosphoprotein of 150kDa,p150TSP,Ctr9,Kiaa0155,Sh2bp1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | IF,IHC,WB |
| 基因名称 | Ctr9 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This Mouse Ctr9 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1022-1056 amino acids from the C-terminal region of Mouse Ctr9. |
| 计算分子量 | 133kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation,acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.PAF1C is required for transcription of Hox and Wnt target genes.PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1.PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys- 4' (H3K4me3).PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1);UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription.PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly (A) factors.Required for mono- and trimethylation on histone H3 'Lys- 4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3).Required for Hox gene transcription (By similarity).Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency;this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex.Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway;may regulate DNA-association of STAT3. |
| Uniprot ID | Q62018 |
相关搜索：Mouse Ctr9抗体，Mouse Ctr9(C-term)多抗，Anti-Mouse Ctr9 Antibody (C-term)